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Chemistry of Biomolecules

Chemistry of Biomolecules I

Course Description

5.451 is a half-semester introduction to natural product biosynthetic pathways. The course covers the assembly of complex polyketide, peptide, terpene and alkaloid structures. Discussion topics include chemical and biochemical strategies used to elucidate natural product pathways.

Lecture Notes

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LEC #TOPICS
1-2Natural Product Biosynthesis (PDF - 2.1 MB)#
3-4Polyketide Biosynthesis (PDF)#
5-6Saccharide Biosynthesis (PDF)#
7-8Shikimate Pathway (PDF)# Shikimate Pathway Flavonoids (PDF)#
9-10Alkaloid Biosynthesis (PDF)# Alkaloid Bioynthesis: Tyrosine Derivatives (PDF)#
11-12Terpene Biosynthesis (PDF 1)# (PDF 2)#

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